Abstract 3184: Tumor-entrained dendritic cells promote ICOS/ICOSL-dependent Th17-like responses in pancreatic adenocarcinoma

@article{Barilla2015Abstract3T,
  title={Abstract 3184: Tumor-entrained dendritic cells promote ICOS/ICOSL-dependent Th17-like responses in pancreatic adenocarcinoma},
  author={R. Barilla and R. Caso and A. Avanzi and Anjlee Panjwani and Xia Zeng and Steve Matthews and D. Tippens and L. Tomkoetter and E. Levie and A. Torres-Hernandez and D. Daley and G. Miller},
  journal={Cancer Research},
  year={2015},
  volume={75},
  pages={3184-3184}
}
BACKGROUND: Ranking 4th among cancer-related deaths worldwide, pancreatic adenocarcinoma (PDAC) boasts a dismal prognosis. The robust immune infiltrate that comprises its tumor microenvironment (TME) can influence disease progression. Tumor rejection by T lymphocytes relies on proper guidance by dendritic cells (DCs). This antigen-education is manifested by the DCs’ expression of co-stimulatory factors, such as ICOS-ligand (ICOSL). In this study, we plan to elucidate the mechanisms used by PDAC… Expand