Abstract 2766: Resistance to radiotherapy and PD-L1 blockade is mediated by TIM-3 upregulation in anti-PD-L1 refractory head and neck cancer

@inproceedings{Oweida2018Abstract2R,
  title={Abstract 2766: Resistance to radiotherapy and PD-L1 blockade is mediated by TIM-3 upregulation in anti-PD-L1 refractory head and neck cancer},
  author={Ayman Oweida and Mohammad K. Hararah and Andy Phan and Shilpa Bhatia and Shelby Lennon and David C Binder and David Raben and Lynn E. Heasley and Eric T Clambey and Raphael A Nemenoff and Sana D. Karam},
  year={2018}
}
Background: Clinical trials targeting the programmed-death ligand axis (PD-1/PD-L1) show that a majority of head and neck squamous cell carcinoma (HNSCC) patients are resistant to PD-1/PD-L1 inhibition. Strategies aimed at sensitizing tumors to immunotherapy can provide durable response compared to conventional therapies. We previously reported that local radiation to the tumor can transform the immune landscape and render poorly immunogenic murine orthotopic HNSCC tumors sensitive to PD-L1… CONTINUE READING