Abstract 2477: The effect of dissociated glucocorticoids on 12-O-tetradecanoylphorbol-13-acetate (TPA) induced skin inflammation in SENCAR mice

@article{Kowalczyk2010Abstract2T,
  title={Abstract 2477: The effect of dissociated glucocorticoids on 12-O-tetradecanoylphorbol-13-acetate (TPA) induced skin inflammation in SENCAR mice},
  author={Piotr Kowalczyk and Renata Sosnowska and Magdalena C. Kowalczyk and O. I. Tolstykh and Jacob J. Junco and Zbigniew Walaszek and Thomas J. Slaga and Margaret Hanausek},
  journal={Cancer Research},
  year={2010},
  volume={70},
  pages={2477-2477}
}
Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC Glucocorticoids are very effective in preventing carcinogen- and tumor promoter-induced skin inflammation, hyperplasia, and mouse skin tumor formation when applied to skin together with a carcinogen. Their control of cellular functions is mediated by a well-known transcription factor, glucocorticoid receptor (GR). GR acts via two different mechanisms: transcriptional regulation that requires DNA-binding and protein…