Abstract 2354: Identification of CDK1 as an aspirin and salicylic acid binding protein: a potential role in chemoprevention

@article{Gunaje2017Abstract2I,
  title={Abstract 2354: Identification of CDK1 as an aspirin and salicylic acid binding protein: a potential role in chemoprevention},
  author={Jayarama B. Gunaje and D. Kumar and Siddharth S. Kesharwani and Eduardo Alberto Callegari and Hemachand Tummala and Rakesh Dachineni},
  journal={Cancer Research},
  year={2017},
  volume={77},
  pages={2354-2354}
}
Data emerging from the past 10 years have consolidated the rationale for investigating the use of aspirin for chemoprevention; however, the mechanisms leading to its anti-cancer effects are still being elucidated. We hypothesized that aspirin’s ability to exert chemopreventive effects may involve altering the levels and activity of cell cycle regulatory proteins. In the present study, using HT-29 colon cancer cells and other cancer cells, we demonstrated that both aspirin and its primary… Expand