• Corpus ID: 83308275

Abstract 18575: The Transcriptional Cofactor Eyes Absent 4 is a Critical Regulator for Maintaining Normal Cardiac Function

@article{Williams2014Abstract1T,
  title={Abstract 18575: The Transcriptional Cofactor Eyes Absent 4 is a Critical Regulator for Maintaining Normal Cardiac Function},
  author={Tatjana Williams and Moritz J. Hundertmark and Peter Nordbeck and Sabine Voll and Anahi-Paula Arias-Loza and Ines Elsner and Daniel Oppelt and Silvana Olivares and Jost Schoenberger and Oliver Ritter},
  journal={Circulation},
  year={2014},
  volume={130}
}
Introduction: E193, a human mutation in the transcription cofactor Eyes absent 4 (EYA4) causes hearing impairment followed by terminal heart failure, defining an important role for Eya4 in maintaining normal cardiac function. METHODS AND RESULTS: First, in-vitro experiments show that overexpression of Eya4 and the mutant isoform alter the expression of p27kip1 on both, transcript and protein levels. Next, we generated transgenic mice with cardiomyocyte-specific Eya4 or E193 overexpression to…