Abstract 1840: Whole-exome somatic mutation analysis of mouse cancer models and implications for preclinical immunomodulatory drug development

@inproceedings{Zeitouni2017Abstract1W,
  title={Abstract 1840: Whole-exome somatic mutation analysis of mouse cancer models and implications for preclinical immunomodulatory drug development},
  author={Bruno Zeitouni and Cordula Tschuch and Jason M. Davis and A L Peille and Yana Raeva and Manuel Landesfeind and Sheri Routt Barnes and J{\"u}rgen Schuler},
  year={2017}
}
Experimental tumors raised in rodents represent an important preclinical tool to develop innovative anticancer compounds before clinical testing. Amongst others such models include solid tumors raised in syngeneic fully immunocompetent hosts and tumors spontaneously growing in genetically engineered mice (GEM) and derivate thereof. These model platforms have gained additional value since the manipulation of the immune system to fight cancer has led to tangible benefits for cancer patients. In… CONTINUE READING

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