Abstract 1710: An anti-apoptotic Bcl-2 family protein index predicts the response of leukemic cells to the pan-Bcl-2 inhibitor S1.

@inproceedings{Liu2013Abstract1A,
  title={Abstract 1710: An anti-apoptotic Bcl-2 family protein index predicts the response of leukemic cells to the pan-Bcl-2 inhibitor S1.},
  author={Yubo Liu and Zhichao Zhang},
  year={2013}
}
Bcl-2-like proteins prevent cell death through expression level, post transcriptional modification, and protein-protein-interaction. Recent studies have shown that antiapoptotic Bcl-2-like members are overexpressed in many haematological malignancies. BH3 mimetics are promising anticancer agents by directly target these proteins and their interactions. S1 (8-oxo-3-thiomorpholin-4-yl-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile) is an authentic BH3 mimetic and a triple inhibitor of Bcl-2, Mcl-1… CONTINUE READING