Abstract 1483: The Role of Genetically Programmed Biases in Th1 and Th2 Immune Responses in Atherogenesis

@inproceedings{Schulte2006Abstract1T,
  title={Abstract 1483: The Role of Genetically Programmed Biases in Th1 and Th2 Immune Responses in Atherogenesis},
  author={Stephanie Schulte and Galina K. Sukhova and Peter Libby},
  year={2006}
}
Background: Inflammation occupies a central position in all phases of atherosclerosis. Atherosclerotic lesions contain predominantly CD4+ T lymphocytes. In response to the local cytokine milieu, CD4+ T cells differentiate into a Th1 or Th2 lineage. The influence of Th1 and Th2 helper cell subsets on atherogenesis was studied in two ApoE−/− mouse strains, C57Bl/6 and Balb/c, displaying opposite T cell subset polarization.n Methods and Results: ApoE−/− Bl/6 mice showed Th1-like immune responses… CONTINUE READING