Abstract 1404: Mitochondrial-targeted nitroxide JP4-039 ameliorates irradiation-induced delay in bone wound healing and inhibits orthotopic tumor growth

@inproceedings{Rwigema2010Abstract1M,
  title={Abstract 1404: Mitochondrial-targeted nitroxide JP4-039 ameliorates irradiation-induced delay in bone wound healing and inhibits orthotopic tumor growth},
  author={Jean-Claude M Rwigema and Abhay S. Gokhale and Michael W. Epperly and Julie Glowackie and Hong Wang and Tracy M Dixon and Ken Patrene and Peter Wipf and Joel S. Greenberger},
  year={2010}
}
In the case of a nuclear explosion, combined injuries will result from radiation dispersal resulting in burns and cellular damage as well as a concussion wave resulting in traumatic bone fractures. Currently no available drugs are available to protect against both irradiation damage and traumatic bone damage. A new mitochondrial targeted small molecule hemigramicidin S nitroxide JP4-039 has been developed and shown to protect against total body irradiation. JP4-039 was tested to determine its… CONTINUE READING