• Corpus ID: 73977193

Abstract 138: Assessing Disability Outcome in Acute Stroke Clinical Trials: Increased Study Power with Linear (ALDS) Compared with Ordinal (mRS) Scales

@article{Chaisinanunkul2014Abstract1A,
  title={Abstract 138: Assessing Disability Outcome in Acute Stroke Clinical Trials: Increased Study Power with Linear (ALDS) Compared with Ordinal (mRS) Scales},
  author={Napasri N. Chaisinanunkul and Sidney Starkman and Jeffrey Gornbein and Scott A. Hamilton and Fiona Chatfield and Robin A Conwit and Jeffrey L. Saver},
  journal={Stroke},
  year={2014},
  volume={45}
}
Background: The most common primary endpoint in acute stroke trials is the modified Rankin Scale (mRS) assessment of global disability. However, the mRS lacks granularity (assigns patients among only 7 broad levels) and is ordinal (scale levels unknown distances apart), constraining study power. Instruments that evaluate disability along an interval, continuous scale theoretically should increase study power. The Academic Medical Center linear disability scale (ALDS) is one such scale… 
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