Abstract 122: Targeting forward and reverse EphB4/EFNB2 signaling by a peptide with dual functions

  title={Abstract 122: Targeting forward and reverse EphB4/EFNB2 signaling by a peptide with dual functions},
  author={Chiyi Xiong and Yunfei Wen and Jun Zhao and Dengke Yin and Lingyun Xu and Anca Chelariu-Raicu and Cody Yao and Xiao Leng and Jinsong Liu and Rajan Chaudhari and Shuxing Zhang and Anil K. Sood and Chun Li},
  • C. Xiong, Yunfei Wen, +10 authors Chun Li
  • Published 2020
  • Medicine
  • Immunology
Although chloroquine administration in vivo following haemorrhage in mice decreases tumour necrosis factor-alpha (TNF-alpha) release by macrophage (M phi), the mechanism remains unknown. To study this, peritoneal M phi (pM phi) from unmanipulated, sham-operated and post-haemorrhage mice were isolated, treated with 0.13 mg/ml chloroquine for 2 hr, and then stimulated with lipopolysaccharide (LPS) for 48 hr. Pretreatment of pM phi from various groups of mice with chloroquine resulted in 75-90… Expand
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