Abstract 1030: Targeting tumor-stroma metabolic symbiosis for head and neck cancer therapy

@inproceedings{Kumar2016Abstract1T,
  title={Abstract 1030: Targeting tumor-stroma metabolic symbiosis for head and neck cancer therapy},
  author={Deepak Kumar and Vikalp Vishwakarma and Jacob New and Wade R. Gutierrez and Sadanand N. Shringare and Partha Kasturi and Ossama Tawfik and Douglas A. Girod and Bennett Van Houten and George Leef and Radhika Joshi and Shary Nicole Shelton and Jeffrey Straub and Yelizaveta Shnayder and Kiran Kakarala and Terance Ted Tsue and Fangchen Lin and Sumana Dasari and Sufi Mary Thomas},
  year={2016}
}
Despite aggressive therapies, head and neck squamous cell carcinoma (HNSCC), which affects 50,000 new patients annually in the United States, is associated with less than 50% 5-year survival. HNSCC tumors display increased glycolysis, even in the presence of oxygen. Consequently, there is an increase in lactic acid (LA) production. However, the effect of lactic acid in the tumor microenvironment and the mechanisms whereby HNSCC tumors survive in highly acidic conditions remain unknown. HNSCC… CONTINUE READING