Abstinence from Cocaine Self-Administration Heightens Neural Encoding of Goal-Directed Behaviors in the Accumbens

@article{Hollander2005AbstinenceFC,
  title={Abstinence from Cocaine Self-Administration Heightens Neural Encoding of Goal-Directed Behaviors in the Accumbens},
  author={Jonathan A Hollander and Regina M Carelli},
  journal={Neuropsychopharmacology},
  year={2005},
  volume={30},
  pages={1464-1474}
}
Cocaine addiction in humans is characterized by cycles of abstinence from drug-taking and relapse. Here, electrophysiological recording procedures were used to determine whether nucleus accumbens (Acb) neuronal firing properties are altered following interruption and resumption of cocaine self-administration. Rats (n=12) were trained to self-administer cocaine (2 h daily sessions) then divided into two groups. Acb activity was recorded for Group 1 (controls) during two additional self… CONTINUE READING

Citations

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View 18 Excerpts
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The Role of Accumbal Hypoactivity in Cocaine Addiction.

TheScientificWorldJournal • 2007
View 5 Excerpts
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Addictive neurons

Therapeutic targets for neurological diseases • 2017

References

Publications referenced by this paper.
Showing 1-10 of 47 references

Phasic firing of single neurons in the rat nucleus accumbens correlated with the timing of intravenous cocaine self-administration.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1996
View 8 Excerpts
Highly Influenced

The Rat Brain in Stereotaxic Coordinates

Trends in Neurosciences • 1984
View 3 Excerpts
Highly Influenced

GABA transmission in the nucleus accumbens is altered after withdrawal from repeated cocaine.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2003
View 2 Excerpts

Glutamate transmission and addiction to cocaine.

Annals of the New York Academy of Sciences • 2003
View 2 Excerpts

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