Absorption of zinc deuteroporphyrin IX 2,4-bis-glycol by the neonatal rat small intestine in vivo.

@article{Vallier1991AbsorptionOZ,
  title={Absorption of zinc deuteroporphyrin IX 2,4-bis-glycol by the neonatal rat small intestine in vivo.},
  author={Heather A. Vallier and Pamela A Rodgers and Ricardo O. Castillo and David K. Stevenson},
  journal={Developmental pharmacology and therapeutics},
  year={1991},
  volume={17 1-2},
  pages={109-15}
}
Zinc deuteroporphyrin IX 2,4-bis-glycol (ZnBG) is a potent inhibitor of heme oxygenase and may be useful in the prevention of neonatal jaundice. Enteral administration could be advantageous clinically, but it has been only minimally effective with other metalloporphyrins in rats and humans. Thus, the absorption of ZnBG by the small intestine in vivo was examined. ZnBG was administered enterally at 40 mumol/kg to 2-week-old suckling rats via in situ catheterization of the small intestine. Within… CONTINUE READING