Absorption of orally administered tritium labelled theophylline preparations

@article{Blow2004AbsorptionOO,
  title={Absorption of orally administered tritium labelled theophylline preparations},
  author={Knut B. B{\"u}low and Hans Larsson},
  journal={Pharmacologia Clinica},
  year={2004},
  volume={1},
  pages={156-160}
}
SummaryThe absorption and excretion of aminophylline, hydroxypropyltheophylline (Theon®) and choline theophyllinate (Choledyl®) after oral administration in capsules were studied by determining theophylline levels in plasma and urine. For comparison, a liquid formula containing choline theophyllinate, Brondaxin Syrup®, was also included in the investigation. — The current spectrophotometric method used by most investigators proved unreliable for measuring low concentrations of theophylline… 
2 Citations

Figures and Tables from this paper

Plasma level and broncholytic effect of choline theophyllinate after a single dose of a press- coated tablet formulation
TLDR
The broncholytic effect and plasma concentrations of theophylline in 10 asthmatic patients were studied and provide a basis for further studies to establish a dosage schedule suitable for prolonged therapy.
Plasma theophylline level and ventilatory function in chronic obstructive pulmonary disease during prolonged oral treatment with choline theophyllinate
TLDR
The results provide a rational basis for determination of an optimal dose schedule for oral treatment with choline theophyllinate to reduce the symptoms of obstructive bronchial disease.

References

SHOWING 1-10 OF 19 REFERENCES
Metabolism of theophylline (1,3-dimethylxanthine) in man.
TLDR
The present paper reports studies on the fate of theophylline in man and describes the isolation and characterization of 1,3:dimethyluric acid, a major transformation product.
Study of Theophylline Plasma Levels after Oral Administration of New Theophylline Compounds
TLDR
In the present investigation five theophylline preparations have been compared in a small group of patients, by studying the plasma levels over a period of five hours, after a single oral dose of equivalent theophyLLine content.
A study of the metabolism of theobromine, theophylline, and caffeine in man.
TLDR
The present investigation concerns the identification and quantitative determination of the methyluric acids and methylxanthines excreted in the urine of man after the ingestion of theobromine, theophylline, and caffeine.
Administration of aminophylline (theophylline ethylenediamine).
TLDR
It is suggested that any therapeutic effect of this drug will be closely related to its level in the blood, since theophylline is restricted to the plasma, does not penetrate the red cell membrane and is only slightly bound to the proteins of the blood.
An ultraviolet spectrophotometric method for the determination of theophylline and theobromine in blood and tissues.
  • J. Schack, S. Waxler
  • Chemistry, Medicine
    The Journal of pharmacology and experimental therapeutics
  • 1949
TLDR
A simple, rapid and accurate ultraviolet spectrophotometric method for the determination of theophylline and theobromine in biological fluids has been developed and application to the tissue of rabbits and mice has been shown.
Tritium-Labeled Compounds I. Radioassay of Tritium-Labeled Compounds in “Infinitely Thick” Films With a Windowless, Gas-Flow, Proportional Counter1
TLDR
A simple, sensitive, and reliable technique has been devised for the radioassay of nonvolatile, water-soluble tritium compounds, which is suitable for routine analyses.
Comparative effectiveness of an alcohol-water solution of theophylline (elixophyllin), alcohol-water solution, and theophylline-water solution for the oral treatment of acute bronchial asthma.
TLDR
Results of control studies clearly indicate that the alcohol present in the preparation is responsible for the "unexpected effects" of theophylline administered orally.
Substituted xanthines. I. Preparation and properties of some choline theophyllinates.
TLDR
Choline was condensed with theophylline and 8-substituted theophylliine to give a series of well-defined, water-soluble theophyLLine derivatives that were found to be a safe and effective drug.
...
1
2
...