Absorption of hemoglobin iron: the role of a heme-splitting substance in the intestinal mucosa.

  title={Absorption of hemoglobin iron: the role of a heme-splitting substance in the intestinal mucosa.},
  author={Lea Weintraub and M B Weinstein and H J Huser and S Rafal},
  journal={The Journal of clinical investigation},
  volume={47 3},
The dog behaves like man in his ability to utilize dietary hemoglobin iron and, therefore, is an excellent model in which to study the mechanisms of absorption. Heme is taken up intact into the epithelial cell of the small intestine but the iron appears in the plasma in a nonheme form. A substance is present in mucosal homogenates which is capable of releasing iron from a hemoglobin substrate in vitro. This has a molecular weight greater than 64,000, and appears to behave as an enzyme. There is… CONTINUE READING


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