Absorption of Nicotine in Cigarette and Cigar Smoke through the Oral Mucosa

@article{Armitage1970AbsorptionON,
  title={Absorption of Nicotine in Cigarette and Cigar Smoke through the Oral Mucosa},
  author={ALAN K. Armitage and David M. Turner},
  journal={Nature},
  year={1970},
  volume={226},
  pages={1231-1232}
}
Nicotine in cigar smoke (pH 8.5) is much more readily absorbed through the mucous membranes of the mouth than is nicotine in cigarette smoke (pH 5.3) because there is a higher concentration of unionized nicotine in the relatively alkaline cigar smoke. 
Absorption of nicotine from small cigars
TLDR
The absorption of nicotine from cigars was measured in 7 male subjects who each smoked a single small cigar containing 14C‐nicotine, and radial plasma concentrations of nicotine were as high as those achieved by cigarette smoking but rose more slowly. Expand
Effects of oral pH on cigarette smoking
TLDR
Oral pH in cigarette smokers was manipulated from pH 5 to 8 by rinses with Sorenson's and McIlvaine's buffers to show differential absorption of nicotine and cross-adaptation of sour to bitter taste, both discussed as explanations for the results. Expand
Mouth versus deep airways absorption of nicotine in cigarette smokers
TLDR
The major finding is that there is virtually no intake of nicotine through the buccal mucosa while smoking American cigarettes, suggesting that nicotine may be a better indicator of exposure to second-hand smoke than carbon monoxide. Expand
Smoke gets in your eyes
into the bloodstream in the undissociated form, this means that cigar smokers can get a pharmacologically active dose through the oral mucosa without inhaling, Cigarette smokers need to inhale toExpand
Smoke gets in your eyes
into the bloodstream in the undissociated form, this means that cigar smokers can get a pharmacologically active dose through the oral mucosa without inhaling, Cigarette smokers need to inhale toExpand
Smoke gets in your eyes
into the bloodstream in the undissociated form, this means that cigar smokers can get a pharmacologically active dose through the oral mucosa without inhaling, Cigarette smokers need to inhale toExpand
Carbon-monoxide absorption by cigarette smokers who change to smoking cigars.
TLDR
It is concluded that cigarette smokers who change to cigar smoking may not lower the risk to their health, and the levels when smoking cigars were similar to those when they were smoking cigarettes. Expand
Pharmacology and Abuse Potential of Cigars
INTRODUCTION Cigar tobacco contains the highly addictive drug nicotine in concentrations similar to those observed in cigarettes; however, since most cigars contain more tobacco, they also containExpand
Buffering capacity of the smoke of different tobaccos in relation to lung cancer risks.
TLDR
The smoker of tobaccos giving a smoke of acid buffering capacity, in order to achieve full nicotine satisfaction, tends to smoke more and to inhale more, thus increasing lung cancer risks, than the smoker of tobacco giving smoke of less acid or of alkalinebuffering capacity. Expand
Metabolism and biochemical effects of nicotine for primary care providers.
TLDR
The absorption and metabolism of nicotine, nicotine toxicity, pharmacologic effects of Nicotine, nicotine-drug interactions, and the use of nicotine for the treatment of disease are covered. Expand
...
1
2
3
4
5
...

References

SHOWING 1-4 OF 4 REFERENCES
Effect of Cigarette, Cigar, and Pipe Smoking on Nicotine Excretion The Influence of Inhaling
TLDR
The nicotine content of the urine was determined during cigarette, cigar, and pipe smoking in man and dog to test the validity of the assumption that the degree of nicotine absorption that occurs with these different forms of smoking affects lipid metabolism and catecholamine activity. Expand
Pharmacological Basis for the Tobacco Smoking Habit
TLDR
Small amounts of nicotine injected intravenously usually increased the lever pressing activity of rats and caused a change in the EEG of cats indicative of cortical activation, consistent with the subjective impression of some smokers that inhalation of tobacco smoke causes them to be more alert and efficient. Expand
The metabolism of [14C] nicotine in the cat.
  • D. Turner
  • Chemistry, Medicine
  • The Biochemical journal
  • 1969
TLDR
The metabolism of [2'-(14)C]nicotine given as an intravenous injection in small doses to anaesthetized and unanaesthetization cats has been studied andabolites of [(14) C]Nicotine have been identified in liver and urine extracts. Expand