Absorption-excipient-pH classification gradient maps: sparingly soluble drugs and the pH partition hypothesis.

@article{Avdeef2008AbsorptionexcipientpHCG,
  title={Absorption-excipient-pH classification gradient maps: sparingly soluble drugs and the pH partition hypothesis.},
  author={Alex Avdeef and Manfred Kansy and Stefanie Bendels and Konstantin L Tsinman},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2008},
  volume={33 1},
  pages={
          29-41
        }
}
This study of sparingly soluble model drugs assesses (a) how pH and the aqueous boundary layer factors may affect in vitro and in vivo absorption, (b) to what extent single excipients (sodium taurocholate, hydroxypropyl-beta-cyclodextrin, KCl, propylene glycol, methylpyrrolidone, and polyethylene glycol 400) can mitigate adverse absorption effects, and (c) how a novel rank-order visualization tool can be applied in high-throughput screening to identify promising single-excipient effects on the… CONTINUE READING
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