Absorption classification of oral drugs based on molecular surface properties.

  title={Absorption classification of oral drugs based on molecular surface properties.},
  author={Christel A. S. Bergstr{\"o}m and Melissa A Strafford and Lucia Lazorova and Alex Avdeef and Kristina Luthman and Per Artursson},
  journal={Journal of medicinal chemistry},
  volume={46 4},
The aim of this study was to investigate whether easily calculated and comprehended molecular surface properties can predict drug solubility and permeability with sufficient accuracy to allow theoretical absorption classification of drug molecules. For this purpose, structurally diverse, orally administered model drugs were selected from the World Health Organization (WHO)'s list of essential drugs. The solubility and permeability of the drugs were determined using well-established in vitro… CONTINUE READING


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