Absorption and metabolism of acetaminophen by the in situ perfused rat small intestine preparation.

@article{Pang1986AbsorptionAM,
  title={Absorption and metabolism of acetaminophen by the in situ perfused rat small intestine preparation.},
  author={K Sandy Pang and Vincent Yuen and Shirin Fayz and J M te Koppele and Gerard J. Mulder},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1986},
  volume={14 1},
  pages={102-11}
}
The in situ perfused rat small intestine preparation was used to examine the extents of segmental absorption and metabolism of acetaminophen (A). Additionally, the preparation was employed to investigate any intestinal excretion of A and its conjugates from the circulation to the intestinal lumen. In this preparation, blood perfusate (300 ml) recirculated the intestinal preparation at 7.5 ml/min, entering via the superior mesenteric artery and returned to the reservoir via the portal vein. To… CONTINUE READING
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