Absorption and glucuronidation of the angiotensin II receptor antagonist losartan by the rat intestine.

@article{Krieter1995AbsorptionAG,
  title={Absorption and glucuronidation of the angiotensin II receptor antagonist losartan by the rat intestine.},
  author={Philip A Krieter and Adria E Colletti and Randy R Miller and Ralph A Stearns},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1995},
  volume={273 2},
  pages={816-22}
}
The absorption and metabolism by the rat intestine of the tetrazole-containing angiotensin II receptor antagonist losartan were determined using in vitro, in situ and in vivo models of absorption. The permeability coefficient of losartan was similar at mucosal concentrations of 0.5 to 2 mM when assayed using segments of jejunum in the Sweetana/Grass diffusion cell. The compound was conjugated during transport to form a glucuronide at the N2-position of the tetrazole group; the structure was… CONTINUE READING