Corpus ID: 9728534

Absorption and excretion of the hydrophobic surfactant, 14C-poloxalene 2930, in the rat.

@article{Rodgers1984AbsorptionAE,
  title={Absorption and excretion of the hydrophobic surfactant, 14C-poloxalene 2930, in the rat.},
  author={J. Rodgers and S. Friday and W. Bochenek},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1984},
  volume={12 5},
  pages={
          631-4
        }
}
Absorption and excretion of 14C-Poloxalene 2930 (PX), a nonionic hydrophobic surfactant of large molecular weight, were studied using bile fistula rats. Approximately half of the dose infused intraduodenally was absorbed and some of the absorbed surfactant was excreted in bile. The remainder was excreted in urine. Only trace quantities of the 14C-PX were recovered in liver and carcass at termination of the study. Two studies were also performed with 14C-PX incorporated into the diet. In the… Expand