Absorption and excretion of paeoniflorin in rats.

  title={Absorption and excretion of paeoniflorin in rats.},
  author={Satoshi Takeda and Takahiro Isono and Yoko Wakui and Yoshimi Matsuzaki and Hiroshi Sasaki and S Amagaya and Motohiko Maruno},
  journal={The Journal of pharmacy and pharmacology},
  volume={47 12A},
The absorption and excretion of paeoniflorin after intravenous and oral administration was studied in rats to evaluate the significance of paeoniflorin in the pharmacological action of Paeony root. The plasma concentration of paeoniflorin after intravenous administration at the doses of 0.5, 2.0 and 5.0 mg kg-1 rapidly decreased, simulated by a biexponential curve, with mean terminal half-lives of 11.0, 9.9 and 12.6 min, respectively. The Vdss values were 0.332, 0. 384 and 0.423 L kg-1 and the… CONTINUE READING

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