Absorption and elimination of formate following oral administration of calcium formate in female human subjects.

@article{Hanzlik2005AbsorptionAE,
  title={Absorption and elimination of formate following oral administration of calcium formate in female human subjects.},
  author={Robert P. Hanzlik and Stephen J Fowler and Janis Thane Eells},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2005},
  volume={33 2},
  pages={282-6}
}
Calcium formate is a water-soluble salt of an essential mineral nutrient with potential for use as a dietary calcium supplement. Formate ion is a product of endogenous and xenobiotic metabolism, but sustained high plasma formate concentrations (such as occur in cases of methanol poisoning) are toxic to the retina and optic nerve. Humans and primates have reduced capacity for formate oxidation compared with rodents and dogs and are thus more sensitive to methanol (and formate) intoxication. To… CONTINUE READING
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