Absorption and disposition of ranitidine hydrochloride in rat and dog.

@article{Eddershaw1996AbsorptionAD,
  title={Absorption and disposition of ranitidine hydrochloride in rat and dog.},
  author={Peter J. Eddershaw and Andy Chadwick and David Higton and Susan H Fenwick and Paul Linacre and William N. Jenner and Jamie A Bell and Gary R. Manchee},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1996},
  volume={26 9},
  pages={
          947-56
        }
}
1. The pharmacokinetics of ranitidine were studied in the male beagle dog at a dose level of 50 mg (intravenous) or 5 mg/kg (oral). 2. After intravenous administration, Clp was moderate (10.4 ml/min/kg) with Clr accounting for approximately 30% of total clearance. Vdarea was 3.5 l/kg, resulting in a t1/2 of approximately 4 h. 3. After oral administration, F was good (73%) with peak plasma concentrations of ranitidine (2 micrograms/ml) achieved within 0.5-1 h hour after dosing. t1/2 (4.1 h) was… CONTINUE READING