Absorption and disposition of econazole nitrate after application to the skins and vaginas of rabbits.

@article{Cameron1976AbsorptionAD,
  title={Absorption and disposition of econazole nitrate after application to the skins and vaginas of rabbits.},
  author={B D Cameron and Leslie F Chasseaud and Brian Conway and Nicole S Fox and Trevor Taylor},
  journal={Arzneimittel-Forschung},
  year={1976},
  volume={26 11},
  pages={2054-9}
}
1. The absorption and tissue distribution of radioactivity has been studied in rabbits after application of a cream containing 10 mg of the 3H-labelled 1-(2,4-dichloro-beta-[(p-chlorobenzyl)oxy]phenethyl) imidazole nitrate (econazole nitrate, Pevaryl) to the normal or abraded skins of rabbits. 2. Approximately one-third of the dose was absorbed through the… CONTINUE READING