Absorption and disposition of 14C-labelled Kathon biocide, a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one, following intravenous or dermal administration to male Sprague-Dawley rats.

@article{deBethizy1986AbsorptionAD,
  title={Absorption and disposition of 14C-labelled Kathon biocide, a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one, following intravenous or dermal administration to male Sprague-Dawley rats.},
  author={J. D. deBethizy and S L Longacre and Ronald Steigerwalt and Fred Deckert and James N � Moss and A. Wallace Hayes and Jacquelin M. Smith and Harvey E Scribner},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1986},
  volume={24 1},
  pages={43-9}
}
Kathon biocide (KB), a 75:25 mixture of 5-chloro-2-methyl-4-isothiazolin-3-one (KI) and 2-methyl-4-isothiazolin-3-one (KII), is a broad-spectrum antimicrobial agent. The absorption and disposition of 14C label were studied in male Sprague-Dawley rats following iv or dermal administration of KB 14C labelled in the carbonyl carbon of either KI or KII. KI-labelled Kathon was distributed rapidly following an iv dose (0.8 mg/kg). Total 14C label in the plasma was rapidly eliminated, with the data… CONTINUE READING

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