Absorption and Presystemic Metabolism of Selegiline Hydrochloride at Different Regions in the Gastrointestinal Tract in Healthy Males

@article{Barrett2004AbsorptionAP,
  title={Absorption and Presystemic Metabolism of Selegiline Hydrochloride at Different Regions in the Gastrointestinal Tract in Healthy Males},
  author={J. Barrett and P. Szego and S. Rohatagi and R. Morales and K. E. DeWitt and G. Rajewski and Joyce Ireland},
  journal={Pharmaceutical Research},
  year={2004},
  volume={13},
  pages={1535-1540}
}
  • J. Barrett, P. Szego, +4 authors Joyce Ireland
  • Published 2004
  • Chemistry, Medicine
  • Pharmaceutical Research
  • AbstractPurpose. The absorption and disposition of selegiline (SEL) and its metabolites N-desmethylselegiline (DMS), L-methamphetamine (MET), and L-amphetamine (AMP) were assessed in 8 healthy male volunteers at proximal and distal regions of the intestine relative to oral administration (in the stomach) to determine if intestinal site dependence contributed to the erratic oral absorption of selegiline hydrochloride which is manifest as low and variable bioavailability. Methods. An open-label… CONTINUE READING
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