Absorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo.

  title={Absorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo.},
  author={Niclas Petri and Christer Tannergren and Birgit Holst and Fred A. Mellon and Yongping Bao and Geoffrey W. Plumb and J. Richard Bacon and Kathleen A. O'Leary and Paul A. Kroon and Lars Knutson and Patrik Forsell and Thomas Eriksson and Hans Lennernas and Gary Williamson},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={31 6},
For the first time the human intestinal effective permeability, estimated from the luminal disappearance and intestinal metabolism of phytochemicals, sulforaphane and quercetin-3,4'-glucoside, as well as the simultaneous changes in gene expression in vivo in enterocytes, has been studied in the human jejunum in vivo (Loc-I-Gut). Both compounds as components of an onion and broccoli extract could readily permeate the enterocytes in the perfused jejunal segment. At the physiologically relevant… 

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