Absorption, utilization and clinical effectiveness of allithiamines compared to water-soluble thiamines.

@article{Baker1976AbsorptionUA,
  title={Absorption, utilization and clinical effectiveness of allithiamines compared to water-soluble thiamines.},
  author={Herman Baker and Oscar Frank},
  journal={Journal of nutritional science and vitaminology},
  year={1976},
  volume={22 SUPPL},
  pages={
          63-8
        }
}
  • H. BakerO. Frank
  • Published 1 August 1976
  • Medicine
  • Journal of nutritional science and vitaminology
Oral administration of lipid-soluble allithiamines [thiamine propyl disulfide (TPD) and thiamine tetrahydrofurfuryl disulfide (TTHF)] rapidly increased thiamine activity in whole blood, red blood cells, cerebrospinal fluid, and urine in normal and thiamine-deficient subjects. These thiamine congeners also restored red blood cell transketolase to normal in alcoholics with thiamine deficiency. Such repletion equaled that produced by parenteral, water-soluble thiamine hydrochloride (THCl) or… 

Kinetics of thiamin and thiamin phosphate esters in human blood, plasma and urine after 50 mg intravenously or orally

Thiamin concentration in plasma was reached after 53 min and the concentration then had increased to 179% of its initial value and the elimination half-life was 154 min, and only 2.5% of the given dose was recovered in the urine, indicating a restricted distribution.

Thiamine transport by erythrocytes and ghosts in thiamine-responsive megaloblastic anaemia

It is concluded that the cells from thiamine-responsive megaloblastic anaemia patients contain low levels of Thiamine compounds, probably due to their inability to take up and retain physiological concentrations ofThiamine, as a result of the lack of the saturable, specific component of transport and reduced thiaminine pyrophosphokinase.

Studies on thiamine metabolism in thiamine-responsive megaloblastic anaemia

It is proposed that the disorder is caused by an inherited defect of thiamine transport, possibly related to deficient pyrophosphokinase activity, leading to intracellular depletion of activeThiamine metabolite derivatives.

Clinical chemistry of thiamin.

Effects of thiamine and benfotiamine on intracellular glucose metabolism and relevance in the prevention of diabetic complications

Clinical trials on diabetic patients would be necessary to test this vitamin as a potential and inexpensive approach to the prevention and/or treatment of diabetic vascular complications, as well as the possible amelioration of neuropathic symptoms.

Evidence for a central cholinergic effect of high‐dose thiamine

Thiamine significantly reduced adverse effects of scopolamine on P3 latency, spectral components of electroencephalography, and memory recall, consistent with a cholinomimetic effect of thiamine in the central nervous system.

The effect of thiamin tetrahydrofurfuryl disulfide on behavior of juvenile DBA/2J mice.

Thiamine deficiency disorders: a clinical perspective

Understanding the clinical diagnosis and global burden of thiamine deficiency will help to implement national surveillance and population‐level prevention programs, with education to sensitize clinicians to TDDs.

Effectiveness of Egg Immersion in Aqueous Solutions of Thiamine and Thiamine Analogs for Reducing Early Mortality Syndrome

Abstract Protocols used for therapeutic thiamine treatments in salmonine early mortality syndrome (EMS) were investigated in lake trout Salvelinus namaycush and coho salmon Oncorhynchus kisutch to

Treatment of autism spectrum children with thiamine tetrahydrofurfuryl disulfide: a pilot study.

Evidence is obtained of an association of this increasingly occurring disease with presence of urinary SH-reactive metals, arsenic in particular, which appears to have a beneficial clinical effect on some autistic children.

References

SHOWING 1-10 OF 13 REFERENCES

Physiol. Rev

  • Physiol. Rev
  • 1972

J. Nutr

  • J. Nutr
  • 1960

Clin. Chim. Acta

  • Clin. Chim. Acta
  • 1964

Ciba Foundation Symposium, Little, Brown and Co

  • Ciba Foundation Symposium, Little, Brown and Co
  • 1967

Am. J. Clin. Nutr

  • Am. J. Clin. Nutr
  • 1968

Am. J. Clin. Nutr

  • Am. J. Clin. Nutr
  • 1971

J. Lab. Clin.Med

  • J. Lab. Clin.Med
  • 1970

Am. J. Clin. Nutr

  • Am. J. Clin. Nutr
  • 1974