Absorption, metabolism, and excretion of paliperidone, a new monoaminergic antagonist, in humans.

@article{Vermeir2008AbsorptionMA,
  title={Absorption, metabolism, and excretion of paliperidone, a new monoaminergic antagonist, in humans.},
  author={Marc Vermeir and Ineke Naessens and Bart M M Remmerie and Geert Mannens and Jan Hendrickx and Patrick Sterkens and Krishna Chaitanya Talluri and Sandra Boom and Marielle Eerdekens and Nancy van Osselaer and Adriaan Cleton},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2008},
  volume={36 4},
  pages={
          769-79
        }
}
Absorption, metabolism, and excretion of paliperidone, an atypical antipsychotic, was studied in five healthy male subjects after a single dose of 1 mg of [(14)C]paliperidone oral solution ( approximately 16 microCi/subject). One week after dosing, 88.4 to 93.8% (mean 91.1%) of the administered radioactivity was excreted: 77.1 to 87.1% (mean 79.6%) in urine and 6.8 to 14.4% (mean 11.4%) in the feces. Paliperidone was the major circulating compound (97% of the area under the plasma concentration… CONTINUE READING

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