Absorption, distribution and excretion of GT31-104, a novel bile acid sequestrant, in rats and dogs after acute and subchronic administration.

Abstract

The absorption, distribution, and excretion of GT31-104, a novel bile acid sequestrant, was studied in rats and dogs after both acute and subchronic oral administration. The polyallylamine backbone of GT31-104 was labeled with tritium and one of the alkyl side chains was labeled with 14C. The mean blood and plasma concentration of [3H, 14C]GT31-104 in rats… (More)

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@article{Rosenbaum1997AbsorptionDA, title={Absorption, distribution and excretion of GT31-104, a novel bile acid sequestrant, in rats and dogs after acute and subchronic administration.}, author={David P Rosenbaum and J\orgen S\oberg Petersen and Simon Ducharme and Philip F. Markham and Deborah Goldberg}, journal={Journal of pharmaceutical sciences}, year={1997}, volume={86 5}, pages={591-5} }