Absorption, distribution and elimination of carnosic acid, a natural antioxidant from Rosmarinus officinalis, in rats.

@article{Doolaege2011AbsorptionDA,
  title={Absorption, distribution and elimination of carnosic acid, a natural antioxidant from Rosmarinus officinalis, in rats.},
  author={Evelyne H A Doolaege and Katleen Raes and Filip de Vos and Roland Verh{\'e} and Stefaan De Smet},
  journal={Plant foods for human nutrition},
  year={2011},
  volume={66 2},
  pages={
          196-202
        }
}
The absorption, distribution and elimination of carnosic acid, the main antioxidant found in rosemary was studied, in vivo, in rats. Therefore, carnosic acid was administrated in a single dose, intravenously (20.5 ± 4.2 mg/kg) and orally (64.3 ± 5.8 mg/kg), to four and nine rats, respectively. Blood samples were collected at different time points, and plasma concentrations of carnosic acid were determined using LC-MS. Furthermore, total collection of urine and feces was done during 4 h and 24 h… CONTINUE READING
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