Absorption, distribution, metabolism and excretion (ADME) of the ALK inhibitor alectinib: results from an absolute bioavailability and mass balance study in healthy subjects.

@article{Morcos2017AbsorptionDM,
  title={Absorption, distribution, metabolism and excretion (ADME) of the ALK inhibitor alectinib: results from an absolute bioavailability and mass balance study in healthy subjects.},
  author={Peter N. Morcos and Li J Yu and Katrijn Bogman and Mika Sato and Hisakazu Katsuki and Kosuke Kawashima and David Moore and Matt Whayman and Keith A Nieforth and Katja Heinig and Elena M. Guerini and Dieter Muri and Meret Martin-Facklam and Alex Phipps},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2017},
  volume={47 3},
  pages={217-229}
}
1. Alectinib is a highly selective, central nervous system-active small molecule anaplastic lymphoma kinase inhibitor. 2. The absolute bioavailability, metabolism, excretion and pharmacokinetics of alectinib were studied in a two-period single-sequence crossover study. A 50 μg radiolabelled intravenous microdose of alectinib was co-administered with a single 600 mg oral dose of alectinib in the first period, and a single 600 mg/67 μCi oral dose of radiolabelled alectinib was administered in the… CONTINUE READING

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In vitro metabolism of alectinib, a novel potent ALK inhibitor, in human: contribution of CYP3A enzymes.

Xenobiotica; the fate of foreign compounds in biological systems • 2018
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