Absorption, distribution, metabolism and excretion of [carbonyl-14C]mosapride citrate after repeated oral administration in rats.

@article{Matsumoto1993AbsorptionDM,
  title={Absorption, distribution, metabolism and excretion of [carbonyl-14C]mosapride citrate after repeated oral administration in rats.},
  author={Shuhei Matsumoto and Masatomo Tagawa and Teruo Hatoyama and Toshihiko Fujii and Hiroyuki Miyazaki and Yokio Sekine},
  journal={Arzneimittel-Forschung},
  year={1993},
  volume={43 10},
  pages={
          1103-8
        }
}
Absorption, distribution, metabolism and excretion of mosapride citrate ((+/-)-4-amino-5-chloro-2-ethoxy-N [[4-(4-fluorobenzyl)-2-morpholinyl]methyl]benzamide citrate, AS-4370, CAS 112885-42-4), a novel gastrokinetic agent, were studied with 14C-labeled compound in male rats during and after 21 consecutive daily oral administration at a dose of 10 mg/kg/d. After the first administration, plasma radioactivity concentrations were essentially equal to those in the single dose experiment, including… CONTINUE READING

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