Absorption, distribution, and excretion of 14C-meglumine in rats and dogs after administration of 14C-meglumine salicylate.

@article{Heeg1977AbsorptionDA,
  title={Absorption, distribution, and excretion of 14C-meglumine in rats and dogs after administration of 14C-meglumine salicylate.},
  author={Jennifer Heeg and G{\"u}nter Born and W V Kessler and Stanley M Shaw and W E Lange},
  journal={Journal of pharmaceutical sciences},
  year={1977},
  volume={66 1},
  pages={96-9}
}
Meglumine labeled with carbon-14 was administered orally as 14C-meglumine salicylate to rats and dogs to study its distribution and excretion. The compound was incompletely absorbed; that which was absorbed was rapidly excreted in the urine. Peak blood levels were about 5-10 mug/ml in rats and 2-8 mug/ml in dogs. Tissue levels were negligible at the end of the experimental periods. No evidence for N-demethylation or oxidation to carbon dioxide was obtained.