Absorption, disposition and metabolism of di-isononyl phthalate (DINP) in F-344 rats.

@article{McKee2002AbsorptionDA,
  title={Absorption, disposition and metabolism of di-isononyl phthalate (DINP) in F-344 rats.},
  author={Richard McKee and M El-Hawari and Maxine L Stoltz and Florian Pallas and Arthur W Lington},
  journal={Journal of applied toxicology : JAT},
  year={2002},
  volume={22 5},
  pages={293-302}
}
Di-isononyl phthalate (DINP; CAS no. 68515-48-0) is a general-purpose plasticizer for polyvinyl chloride. It produced liver and kidney effects when given to rodents at high oral doses, but there were no target organ effects in primates treated under similar conditions. To assist in understanding the basis for these species differences, the pharmacokinetic properties of DINP were evaluated in rodents following both oral and dermal administration. These studies demonstrated that the… CONTINUE READING
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