Absorption, Metabolism, and Excretion of Paliperidone, a New Monoaminergic Antagonist, in Humans

@article{Vermeir2008AbsorptionMA,
  title={Absorption, Metabolism, and Excretion of Paliperidone, a New Monoaminergic Antagonist, in Humans},
  author={Marc Vermeir and Ineke Naessens and Bart Remmerie and Geert Mannens and Jan F. A. Hendrickx and Patrick Sterkens and K. Talluri and Sandra P. A. Boom and Mari{\"e}lle Eerdekens and Nancy van Osselaer and Adriaan Cleton},
  journal={Drug Metabolism and Disposition},
  year={2008},
  volume={36},
  pages={769 - 779}
}
Absorption, metabolism, and excretion of paliperidone, an atypical antipsychotic, was studied in five healthy male subjects after a single dose of 1 mg of [14C]paliperidone oral solution (∼16 μCi/subject). One week after dosing, 88.4 to 93.8% (mean 91.1%) of the administered radioactivity was excreted: 77.1 to 87.1% (mean 79.6%) in urine and 6.8 to 14.4% (mean 11.4%) in the feces. Paliperidone was the major circulating compound (97% of the area under the plasma concentration-time curve at 24 h… 

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