Absorption, Metabolism, and Excretion of Paliperidone, a New Monoaminergic Antagonist, in Humans

  title={Absorption, Metabolism, and Excretion of Paliperidone, a New Monoaminergic Antagonist, in Humans},
  author={Marc Vermeir and Ineke Naessens and Bart Remmerie and G. S. J. Mannens and Jan F. A. Hendrickx and Patrick Sterkens and K. Talluri and Sandra P. A. Boom and Mari{\"e}lle Eerdekens and Nancy van Osselaer and Adriaan Cleton},
  journal={Drug Metabolism and Disposition},
  pages={769 - 779}
Absorption, metabolism, and excretion of paliperidone, an atypical antipsychotic, was studied in five healthy male subjects after a single dose of 1 mg of [14C]paliperidone oral solution (∼16 μCi/subject). One week after dosing, 88.4 to 93.8% (mean 91.1%) of the administered radioactivity was excreted: 77.1 to 87.1% (mean 79.6%) in urine and 6.8 to 14.4% (mean 11.4%) in the feces. Paliperidone was the major circulating compound (97% of the area under the plasma concentration-time curve at 24 h… 

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