Absorption, Metabolism, and Excretion of Paliperidone, a New Monoaminergic Antagonist, in Humans

  title={Absorption, Metabolism, and Excretion of Paliperidone, a New Monoaminergic Antagonist, in Humans},
  author={M. Vermeir and I. Naessens and B. Remmerie and G. Mannens and J. Hendrickx and P. Sterkens and K. Talluri and S. Boom and M. Eerdekens and N. van Osselaer and A. Cleton},
  journal={Drug Metabolism and Disposition},
  pages={769 - 779}
  • M. Vermeir, I. Naessens, +8 authors A. Cleton
  • Published 2008
  • Medicine, Chemistry
  • Drug Metabolism and Disposition
  • Absorption, metabolism, and excretion of paliperidone, an atypical antipsychotic, was studied in five healthy male subjects after a single dose of 1 mg of [14C]paliperidone oral solution (∼16 μCi/subject). One week after dosing, 88.4 to 93.8% (mean 91.1%) of the administered radioactivity was excreted: 77.1 to 87.1% (mean 79.6%) in urine and 6.8 to 14.4% (mean 11.4%) in the feces. Paliperidone was the major circulating compound (97% of the area under the plasma concentration-time curve at 24 h… CONTINUE READING

    Paper Mentions

    The purposes of this study are to investigate the metabolic pathways of paliperidone and excretion of paliperidone and its metabolites in healthy adult male volunteers, both CYP2D6… Expand
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