Absolute requirement of macrophages for the development and activation of beta-cell cytotoxic CD8+ T-cells in T-cell receptor transgenic NOD mice.

@article{Jun1999AbsoluteRO,
  title={Absolute requirement of macrophages for the development and activation of beta-cell cytotoxic CD8+ T-cells in T-cell receptor transgenic NOD mice.},
  author={Hee-Sook Jun and Pere Santamaria and Hyung Woo Lim and Mei Lan Zhang and J. W. Yoon},
  journal={Diabetes},
  year={1999},
  volume={48 1},
  pages={34-42}
}
The development of autoimmune diabetes in NOD mice results from selective destruction of beta-cells by a T-cell-dependent autoimmune process. However, the mechanisms that control the generation of beta-cell cytotoxic T-cells in vivo are poorly understood. We recently established 8.3-T-cell receptor (TCR)-beta transgenic NOD mice that show a selective acceleration of the recruitment of CD8+ T-cells into the islets of prediabetic animals, resulting in rapid beta-cell destruction and early onset… CONTINUE READING