Absolute requirement of aryl hydrocarbon receptor nuclear translocator protein for gene activation by hypoxia.

@article{Salceda1996AbsoluteRO,
  title={Absolute requirement of aryl hydrocarbon receptor nuclear translocator protein for gene activation by hypoxia.},
  author={S V Salceda and Irmtraud Beck and Jaime Caro},
  journal={Archives of biochemistry and biophysics},
  year={1996},
  volume={334 2},
  pages={389-94}
}
Hypoxia-inducible factor 1 (HIF-1) is a DNA-binding heterodimeric protein complex originally described in the transcriptional activation of the erythropoietin gene by hypoxia. This protein complex is composed of two subunits, HIF-1alpha and -1beta (aryl hydrocarbon receptor nuclear translocator, ARNT). In this study, we used ARNT-deficient cells, derived from the mouse hepatoma cell line Hepa1c1c7, to further characterize HIF-1 complex formation and its relationship with gene activation by… CONTINUE READING
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