Absolute rates of globin gene transcription and mRNA formation during differentiation of cultured mouse erythroleukemia cells.

@article{Ganguly1985AbsoluteRO,
  title={Absolute rates of globin gene transcription and mRNA formation during differentiation of cultured mouse erythroleukemia cells.},
  author={Subinay Ganguly and Arthur I. Skoultchi},
  journal={The Journal of biological chemistry},
  year={1985},
  volume={260 22},
  pages={12167-73}
}
We have compared the rates of alpha- and beta-globin gene transcription with the rates of mature globin mRNA appearance in the cytoplasm during the course of chemically induced differentiation of mouse erythroleukemia cells by in vivo pulse-labeling experiments. The absolute rates for both processes were determined by simultaneously measuring incorporation… CONTINUE READING