Absolute quantification of proteins by LCMSE: a virtue of parallel MS acquisition.

@article{Silva2006AbsoluteQO,
  title={Absolute quantification of proteins by LCMSE: a virtue of parallel MS acquisition.},
  author={Jeffrey C Silva and Marc V. Gorenstein and Guo-Zhong Li and Johannes P C Vissers and Scott J. Geromanos},
  journal={Molecular & cellular proteomics : MCP},
  year={2006},
  volume={5 1},
  pages={144-56}
}
Relative quantification methods have dominated the quantitative proteomics field. There is a need, however, to conduct absolute quantification studies to accurately model and understand the complex molecular biology that results in proteome variability among biological samples. A new method of absolute quantification of proteins is described. This method is based on the discovery of an unexpected relationship between MS signal response and protein concentration: the average MS signal response… CONTINUE READING
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