Absolute quantification and differential expression of drug transporters, cytochrome P450 enzymes, and UDP-glucuronosyltransferases in cultured primary human hepatocytes.

@article{Schaefer2012AbsoluteQA,
  title={Absolute quantification and differential expression of drug transporters, cytochrome P450 enzymes, and UDP-glucuronosyltransferases in cultured primary human hepatocytes.},
  author={Olaf Schaefer and Sumio Ohtsuki and Hirotaka Kawakami and Tae Inoue and Stephanie Liehner and Asami Saito and Atsushi Sakamoto and Naoki Ishiguro and Takehisa Matsumaru and Tetsuya Terasaki and Thomas Ebner},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2012},
  volume={40 1},
  pages={93-103}
}
The levels of metabolizing enzymes and transporters expressed in hepatocytes are decisive factors for hepatobiliary disposition of most drugs. Induction via nuclear receptor activation can significantly alter those levels, with the coregulation of multiple enzymes and transporters occurring to different extents. Here, we report the use of a targeted liquid… CONTINUE READING