Absolute macrophage dependency of T lymphocyte activation by mitogens.

  title={Absolute macrophage dependency of T lymphocyte activation by mitogens.},
  author={David L. Rosenstreich and J. J. Farrar and Shona Dougherty},
  journal={Journal of immunology},
  volume={116 1},
A T lymphocyte subpopulation that contains only 0.3% macrophages and less than 2% B lymphocytes has been prepared from guinea pig lymph node cells by the use of two different types of adherence columns. This subpopulation does not porliferate in response to the mitogens Con A or PHA unless additional macrophages are added. The means by which macrophages restore T cell responsiveness to PHA has been investigated. Marcophages appear to function via two different distinct mechanisms in this… CONTINUE READING