Absolute difference of hepatobiliary transporter multidrug resistance-associated protein (MRP2/Mrp2) in liver tissues and isolated hepatocytes from rat, dog, monkey, and human.

Abstract

We previously reported that hepatobiliary transporter multidrug resistance-associated protein (MRP2/Mrp2) is considered to be the major cause of the interspecies differences detected by efflux of fluorescent substrates in isolated hepatocytes. In the present study, the interspecies differences of MRP2/Mrp2 were first evaluated by quantitative real-time… (More)
DOI: 10.1124/dmd.108.023234

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@article{Li2009AbsoluteDO, title={Absolute difference of hepatobiliary transporter multidrug resistance-associated protein (MRP2/Mrp2) in liver tissues and isolated hepatocytes from rat, dog, monkey, and human.}, author={Na Li and Yiqun Zhang and Fengmei Hua and Yurong Lai}, journal={Drug metabolism and disposition: the biological fate of chemicals}, year={2009}, volume={37 1}, pages={66-73} }