Absolute bioavailability and pharmacokinetics of avosentan in man.

Abstract

OBJECTIVE Avosentan is a potent, selective endothelin A receptor blocker. The pharmacokinetics of avosentan were investigated in healthy male and female volunteers, following oral and i.v. administration of single doses of avosentan and its absolute bioavailability was determined. METHODS In a randomized, balanced open-label, three-period oral crossover… (More)

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Cite this paper

@article{Dieterle2009AbsoluteBA, title={Absolute bioavailability and pharmacokinetics of avosentan in man.}, author={Werner Dieterle and Thomas Hengelage}, journal={International journal of clinical pharmacology and therapeutics}, year={2009}, volume={47 9}, pages={587-94} }