Absolute Quantification of Selected Proteins in the Human Osteoarthritic Secretome

  title={Absolute Quantification of Selected Proteins in the Human Osteoarthritic Secretome},
  author={Mandy J Peffers and Robert J Beynon and Peter David Clegg},
  booktitle={International journal of molecular sciences},
Osteoarthritis (OA) is characterized by a loss of extracellular matrix which is driven by catabolic cytokines. Proteomic analysis of the OA cartilage secretome enables the global study of secreted proteins. These are an important class of molecules with roles in numerous pathological mechanisms. Although cartilage studies have identified profiles of secreted proteins, quantitative proteomics techniques have been implemented that would enable further biological questions to be addressed. To… CONTINUE READING
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Proteomic and Transcriptomic Signatures in Cartilage Ageing and Disease

  • M. P. Peffers
  • Ph.D. Thesis,
  • 2013
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