Absence seizures: A review of recent reports with new concepts

@article{Hughes2009AbsenceSA,
  title={Absence seizures: A review of recent reports with new concepts},
  author={John Russell Hughes},
  journal={Epilepsy \& Behavior},
  year={2009},
  volume={15},
  pages={404-412}
}
  • J. R. Hughes
  • Published 1 August 2009
  • Biology
  • Epilepsy & Behavior
View on Elsevier
doi.org
118 Citations
Highly Influential Citations
5
Background Citations
43
Methods Citations
3
Results Citations
2

118 Citations

Pathophysiology of absence epilepsy: Insights from genetic models
Neurochemical and Behavioral Features in Genetic Absence Epilepsy and in Acutely Induced Absence Seizures
TLDR
Two mechanisms that cause an infringement of the function of DA receptors in this genetic absence epilepsy model are proposed.
The cortical focus in childhood absence epilepsy; evidence from nonlinear analysis of scalp EEG recordings
Semiology, clustering, periodicity and natural history of seizures in an experimental occipital cortical epilepsy model
TLDR
The TeNT model of occipital cortical epilepsy is a model of acquired focal neocortical epilepsy that is well-suited for preclinical evaluation of novel anti-epileptic strategies and a predictive framework that can be used to reduce variation and consequently animal use in preclinical studies of potential treatments.
Current advances in childhood absence epilepsy.
Semiology, clustering, periodicity and natural history of seizures in an experimental visual cortical epilepsy model
TLDR
A detailed analysis of the epilepsy phenotype, seizure activity, electrographic features, and the semiology is provided to provide a predictive framework that can be used to reduce variation and consequently animal use in pre-clinical studies of potential treatments.
A brief history of typical absence seizures — Petit mal revisited
Spectral Power of 1–4 Hz Frequency in the Ictal Phase of Childhood Absence Epilepsy
  • D. Kim, D. Nordli, F. Zelko
  • Psychology
    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society
  • 2011
TLDR
These observations bolster the new ILAE definition of generalized seizures, suggesting that some so-called generalized seizures are not truly generalized but that they instead rapidly engage bilaterally distributed networks with clear asymmetries of scalp electrical discharges.
Coexistence of childhood absence epilepsy and benign epilepsy with centrotemporal spikes: A case series.
  • A. Verrotti, S. Casciato, G. Di Gennaro
  • Medicine, Psychology
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
  • 2017
[A late-onset case of nonconvulsive status epilepticus of generalized epilepsy].
TLDR
Her symptoms improved, and interictal epileptic discharges extremely decreased, and this case was discussed as an important case for diagnosis of NCSE with subtle symptom of dizziness.
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References

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Are absences truly generalized seizures or partial seizures originating from or predominantly involving the pre-motor areas? Some clinical and theoretical observations and their implications for seizure classification
Absences in adult seizure disorders
  • E. Trinka
  • Psychology
    Acta neurologica Scandinavica. Supplementum
  • 2005
TLDR
A large number of patients suffer from absences late into adulthood, which are often refractory to antiepileptic drugs, and need to be carefully distinguished from later aggravation or semiological transformation of undiagnosed childhood epilepsies and from certain complex focal seizures originating from the frontal or temporal lobe.
Electroclinical features of absence seizures in childhood absence epilepsy
TLDR
The heterogeneous nature of each clinical and EEG feature of untreated absence seizures is of critical importance when determining criteria for childhood absence epilepsy.
Global and focal aspects of absence epilepsy: The contribution of genetic models
Occipital intermittent rhythmic delta activity in absence epilepsy.
TLDR
Electroclinical evolution in 14 patients with TA and OIRDA with onset before 10 years, pyknolepsy as common finding and few GTCS is observed and it is suggested that OIRda could be considered good prognostic factor in TA associated with SWC and of epileptiform nature leading to appropriate investigation.
Typical childhood absence seizures are associated with thalamic activation.
TLDR
Thalamic activation in typical, untreated childhood absence epilepsy is demonstrated, and the cortical signal change may be related to a thalamo-cortical circuit.
Evolving concepts on the pathophysiology of absence seizures: the cortical focus theory.
TLDR
The "cortical focus" theory for generalized absence epilepsy bridges cortical and thalamic theories and shows a consistent focus within the perioral region of the somatosensory cortex.
Typical absence epilepsy presenting prior to age of 3 years: an uncommon form of idiopathic generalized epilepsy.
Idiopathic Generalized Epilepsies of Adolescence
TLDR
The cognitive and behavioral aspects of these patients suggest an involvement of frontal lobes, and patients with IGEs appear to lack a degree of self‐control, to neglect their physical needs, and are poorly compliant with therapy.
MRI volumetry shows increased anterior thalamic volumes in patients with absence seizures
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