Absence seizures: A review of recent reports with new concepts

@article{Hughes2009AbsenceSA,
  title={Absence seizures: A review of recent reports with new concepts},
  author={John Russell Hughes},
  journal={Epilepsy \& Behavior},
  year={2009},
  volume={15},
  pages={404-412}
}
  • J. R. Hughes
  • Published 1 August 2009
  • Biology
  • Epilepsy & Behavior
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Two mechanisms that cause an infringement of the function of DA receptors in this genetic absence epilepsy model are proposed.
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A detailed analysis of the epilepsy phenotype, seizure activity, electrographic features, and the semiology is provided to provide a predictive framework that can be used to reduce variation and consequently animal use in pre-clinical studies of potential treatments.
Spectral Power of 1–4 Hz Frequency in the Ictal Phase of Childhood Absence Epilepsy
  • D. Kim, D. Nordli, F. Zelko
  • Psychology
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  • 2011
TLDR
These observations bolster the new ILAE definition of generalized seizures, suggesting that some so-called generalized seizures are not truly generalized but that they instead rapidly engage bilaterally distributed networks with clear asymmetries of scalp electrical discharges.
Coexistence of childhood absence epilepsy and benign epilepsy with centrotemporal spikes: A case series.
  • A. Verrotti, S. Casciato, G. Di Gennaro
  • Medicine, Psychology
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
  • 2017
[A late-onset case of nonconvulsive status epilepticus of generalized epilepsy].
TLDR
Her symptoms improved, and interictal epileptic discharges extremely decreased, and this case was discussed as an important case for diagnosis of NCSE with subtle symptom of dizziness.
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Absences in adult seizure disorders
  • E. Trinka
  • Psychology
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  • 2005
TLDR
A large number of patients suffer from absences late into adulthood, which are often refractory to antiepileptic drugs, and need to be carefully distinguished from later aggravation or semiological transformation of undiagnosed childhood epilepsies and from certain complex focal seizures originating from the frontal or temporal lobe.
Electroclinical features of absence seizures in childhood absence epilepsy
TLDR
The heterogeneous nature of each clinical and EEG feature of untreated absence seizures is of critical importance when determining criteria for childhood absence epilepsy.
Global and focal aspects of absence epilepsy: The contribution of genetic models
Occipital intermittent rhythmic delta activity in absence epilepsy.
TLDR
Electroclinical evolution in 14 patients with TA and OIRDA with onset before 10 years, pyknolepsy as common finding and few GTCS is observed and it is suggested that OIRda could be considered good prognostic factor in TA associated with SWC and of epileptiform nature leading to appropriate investigation.
Typical childhood absence seizures are associated with thalamic activation.
TLDR
Thalamic activation in typical, untreated childhood absence epilepsy is demonstrated, and the cortical signal change may be related to a thalamo-cortical circuit.
Evolving concepts on the pathophysiology of absence seizures: the cortical focus theory.
TLDR
The "cortical focus" theory for generalized absence epilepsy bridges cortical and thalamic theories and shows a consistent focus within the perioral region of the somatosensory cortex.
Typical absence epilepsy presenting prior to age of 3 years: an uncommon form of idiopathic generalized epilepsy.
Idiopathic Generalized Epilepsies of Adolescence
TLDR
The cognitive and behavioral aspects of these patients suggest an involvement of frontal lobes, and patients with IGEs appear to lack a degree of self‐control, to neglect their physical needs, and are poorly compliant with therapy.
MRI volumetry shows increased anterior thalamic volumes in patients with absence seizures
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