Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis.

@article{Hall2010AbsenceOT,
  title={Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis.},
  author={Jessica A. Hall and Scott A Ribich and Marcelo Augusto Christoffolete and Gordana Simovic and Mayrin Correa-Medina and Mary Elizabeth Patti and Antonio Carlos Mugayar Bianco},
  journal={Endocrinology},
  year={2010},
  volume={151 9},
  pages={4573-82}
}
Type 2 deiodinase (D2), which is highly expressed in brown adipose tissue (BAT), is an enzyme that amplifies thyroid hormone signaling in individual cells. Mice with inactivation of the D2 pathway (D2KO) exhibit dramatically impaired thermogenesis in BAT, leading to hypothermia during cold exposure and a greater susceptibility to diet-induced obesity. This… CONTINUE READING