Absence of the chemokine receptor CCR2 protects against cerebral ischemia/reperfusion injury in mice.

@article{Dimitrijevic2007AbsenceOT,
  title={Absence of the chemokine receptor CCR2 protects against cerebral ischemia/reperfusion injury in mice.},
  author={Oliver B Dimitrijevic and Svetlana M. Stamatovic and Richard F. Keep and Anuska V. Andjelkovic},
  journal={Stroke},
  year={2007},
  volume={38 4},
  pages={1345-53}
}
BACKGROUND AND PURPOSE The chemokine, monocyte chemoattractant protein-1 (CCL2), is a major factor driving leukocyte infiltration into the brain parenchyma in a variety of neuropathologic conditions associated with inflammation, including stroke. In addition, recent studies indicate that CCL2 and its receptor (CCR2) could have an important role in regulating blood-brain barrier (BBB) permeability. This study evaluated the role of the CCL2/CCR2 axis in regulating postischemic inflammation, BBB… CONTINUE READING